Motif ID: ELK1,4_GABP{A,B1}.p3

Z-value: 3.040


Transcription factors associated with ELK1,4_GABP{A,B1}.p3:

Gene SymbolEntrez IDGene Name
ELK1 2002 ELK1, member of ETS oncogene family
ELK4 2005 ELK4, ETS-domain protein (SRF accessory protein 1)
GABPA 2551 GA binding protein transcription factor, alpha subunit 60kDa
GABPB1 2553 GA binding protein transcription factor, beta subunit 1



Activity profile for motif ELK1,4_GABP{A,B1}.p3.

activity profile for motif ELK1,4_GABP{A,B1}.p3


Sorted Z-values histogram for motif ELK1,4_GABP{A,B1}.p3

Sorted Z-values for motif ELK1,4_GABP{A,B1}.p3



Network of associatons between targets according to the STRING database.



First level regulatory network of ELK1,4_GABP{A,B1}.p3

PNG image of the network

In order to view interactive SVG image please either update your browser to latest version or install SVG plugin.


View svg image
View png image


Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr15_+_72620570 3.332 NM_006465
ARID3B
AT rich interactive domain 3B (BRIGHT-like)
chr22_+_20350272 3.041 NM_014337
NM_148175
NM_148176
PPIL2


peptidylprolyl isomerase (cyclophilin)-like 2


chr17_+_4784524 2.807 RNF167
ring finger protein 167
chr16_+_65783571 2.592 E2F4
E2F transcription factor 4, p107/p130-binding
chr16_+_65783528 2.562 NM_001950
E2F4
E2F transcription factor 4, p107/p130-binding
chr19_-_17349096 2.545 NM_031310
PLVAP
plasmalemma vesicle associated protein
chr12_+_118590039 2.229 NM_006253
PRKAB1
protein kinase, AMP-activated, beta 1 non-catalytic subunit
chr16_-_48960186 2.207 NM_001173984
NM_013263
BRD7

bromodomain containing 7

chr12_-_47698781 2.158 NM_002733
NM_212461
PRKAG1

protein kinase, AMP-activated, gamma 1 non-catalytic subunit

chr16_+_65783599 2.148 E2F4
E2F transcription factor 4, p107/p130-binding
chr17_-_71017509 2.107 NM_001142643
CASKIN2
CASK interacting protein 2
chr2_+_169367345 1.999 NM_001039724
NM_001171632
NM_052946
NOSTRIN


nitric oxide synthase trafficker


chr22_-_17798998 1.991 HIRA
HIR histone cell cycle regulation defective homolog A (S. cerevisiae)
chr2_+_33514896 1.951 NM_170672
RASGRP3
RAS guanyl releasing protein 3 (calcium and DAG-regulated)
chr1_+_36169260 1.932 NM_024852
NM_177422
EIF2C3

eukaryotic translation initiation factor 2C, 3

chr16_-_1999760 1.930 NM_178167
ZNF598
zinc finger protein 598
chr2_-_74915722 1.873


chr9_-_122595475 1.860 NM_012164
FBXW2
F-box and WD repeat domain containing 2
chr2_+_128565269 1.765 UGGT1
UDP-glucose glycoprotein glucosyltransferase 1
chr6_-_168219380 1.734 NM_001122841
FRMD1
FERM domain containing 1
chr20_+_21231921 1.714 NM_012255
XRN2
5'-3' exoribonuclease 2
chr2_+_65308332 1.701 NM_001005386
NM_005722
ACTR2

ARP2 actin-related protein 2 homolog (yeast)

chr17_+_72596349 1.680 SEC14L1
C17orf86
SEC14-like 1 (S. cerevisiae)
chromosome 17 open reading frame 86
chr7_-_107997132 1.661 NM_182529
NM_001130475
THAP5

THAP domain containing 5

chr4_-_76658606 1.634 NM_001008925
NM_001009922
NM_015436
RCHY1


ring finger and CHY zinc finger domain containing 1


chr11_-_67795903 1.620 C11orf24
chromosome 11 open reading frame 24
chr4_+_76658677 1.616 NM_144721
THAP6
THAP domain containing 6
chr1_-_32888677 1.615 NM_178547
ZBTB8OS
zinc finger and BTB domain containing 8 opposite strand
chr3_-_184756101 1.598 NM_130446
KLHL6
kelch-like 6 (Drosophila)
chr9_-_133141726 1.593 NM_033387
FAM78A
family with sequence similarity 78, member A
chr4_-_76658503 1.577 RCHY1
ring finger and CHY zinc finger domain containing 1
chr6_+_170705345 1.574 NM_001172085
NM_003194
TBP

TATA box binding protein

chr21_+_46530654 1.557 NM_001006114
NM_058181
YBEY

ybeY metallopeptidase (putative)

chr19_+_45914755 1.552 NM_025194
ITPKC
inositol 1,4,5-trisphosphate 3-kinase C
chr20_-_44426407 1.546 NM_015945
NM_173073
NM_173179
SLC35C2


solute carrier family 35, member C2


chr2_-_65308220 1.534 LOC729324
hCG1986447
chr1_-_170679830 1.520 PIGC
phosphatidylinositol glycan anchor biosynthesis, class C
chr3_-_168935287 1.511 NM_007217
NM_145860
NM_145859
PDCD10


programmed cell death 10


chr5_+_147743734 1.509 NM_030793
NM_205836
FBXO38

F-box protein 38

chr1_-_170679794 1.497 PIGC
phosphatidylinositol glycan anchor biosynthesis, class C
chr1_-_170679833 1.486 NM_002642
NM_153747
PIGC

phosphatidylinositol glycan anchor biosynthesis, class C

chr6_+_111409933 1.482 NM_032194
RPF2
ribosome production factor 2 homolog (S. cerevisiae)
chr8_+_145553016 1.479 NM_024531
GPR172A
G protein-coupled receptor 172A
chr9_-_122595349 1.475 FBXW2
F-box and WD repeat domain containing 2
chr9_+_35722629 1.472 CREB3
cAMP responsive element binding protein 3
chr6_-_166675980 1.471 NM_145169
SFT2D1
SFT2 domain containing 1
chr5_+_147743753 1.467 FBXO38
F-box protein 38
chr6_-_166676016 1.457 SFT2D1
SFT2 domain containing 1
chr16_+_67931178 1.453 NIP7
nuclear import 7 homolog (S. cerevisiae)
chr2_+_101235782 1.435 C2orf29
chromosome 2 open reading frame 29
chr16_-_1999796 1.433 ZNF598
zinc finger protein 598
chr3_+_32701663 1.431 NM_015442
CNOT10
CCR4-NOT transcription complex, subunit 10
chr10_+_112247614 1.431 NM_004419
DUSP5
dual specificity phosphatase 5
chr15_-_63596656 1.426 NM_197960
DPP8
dipeptidyl-peptidase 8
chr3_+_133861894 1.422 UBA5
ubiquitin-like modifier activating enzyme 5
chr4_-_159863889 1.418 NM_005038
PPID
peptidylprolyl isomerase D
chr12_-_48248132 1.412 NM_006337
MCRS1
microspherule protein 1
chr3_+_9809776 1.411 NM_001198780
ARPC4
actin related protein 2/3 complex, subunit 4, 20kDa
chr7_-_99355051 1.397 TRIM4
tripartite motif containing 4
chr9_+_131605270 1.389 TOR1B
torsin family 1, member B (torsin B)
chr6_+_30693464 1.387 NM_014046
MRPS18B
mitochondrial ribosomal protein S18B
chr15_-_62435267 1.373 CSNK1G1
casein kinase 1, gamma 1
chr16_-_70400393 1.371 NM_001030007
NM_001128
AP1G1

adaptor-related protein complex 1, gamma 1 subunit

chr16_-_70400232 1.368 AP1G1
adaptor-related protein complex 1, gamma 1 subunit
chr4_-_153675602 1.348 NM_033632
FBXW7
F-box and WD repeat domain containing 7
chr6_-_32268267 1.348 GPSM3
G-protein signaling modulator 3
chr6_-_151754337 1.333 NM_020861
ZBTB2
zinc finger and BTB domain containing 2
chr19_-_45914618 1.329 NM_024876
ADCK4
aarF domain containing kinase 4
chr21_-_37561463 1.328 DSCR3
Down syndrome critical region gene 3
chr1_-_85497903 1.328 NM_198077
C1orf52
chromosome 1 open reading frame 52
chr1_-_52272020 1.317 NM_138417
KTI12
KTI12 homolog, chromatin associated (S. cerevisiae)
chr7_-_99536214 1.301 NM_182776
MCM7
minichromosome maintenance complex component 7
chr17_-_53282376 1.286 NM_016070
MRPS23
mitochondrial ribosomal protein S23
chr2_+_98591516 1.286 UNC50
unc-50 homolog (C. elegans)
chr3_+_198153865 1.283 LOC152217
hypothetical LOC152217
chr12_-_122415327 1.274 SBNO1
strawberry notch homolog 1 (Drosophila)
chr6_-_28475478 1.272 NM_001163391
ZSCAN12
zinc finger and SCAN domain containing 12
chr7_+_104959767 1.271 NM_021930
RINT1
RAD50 interactor 1
chr16_+_87811585 1.271 NM_182531
ZNF778
zinc finger protein 778
chr2_-_152740387 1.268 NM_005843
STAM2
signal transducing adaptor molecule (SH3 domain and ITAM motif) 2
chr20_+_43028533 1.268 NM_006282
STK4
serine/threonine kinase 4
chr15_-_62435412 1.262 NM_022048
CSNK1G1
casein kinase 1, gamma 1
chr1_+_37712767 1.258 ZC3H12A
zinc finger CCCH-type containing 12A
chr7_+_106292932 1.256 PIK3CG
phosphoinositide-3-kinase, catalytic, gamma polypeptide
chr2_+_220170804 1.251 NM_052902
STK11IP
serine/threonine kinase 11 interacting protein
chr5_+_148705169 1.243 NM_152407
GRPEL2
GrpE-like 2, mitochondrial (E. coli)
chr6_-_36950520 1.243 PPIL1
peptidylprolyl isomerase (cyclophilin)-like 1
chr11_-_67796022 1.240 NM_022338
C11orf24
chromosome 11 open reading frame 24
chr2_+_98591473 1.234 NM_014044
UNC50
unc-50 homolog (C. elegans)
chr5_+_34692124 1.223 NM_001145522
NM_015577
RAI14

retinoic acid induced 14

chr16_+_21926939 1.222 NM_001164579
C16orf52
chromosome 16 open reading frame 52
chr7_+_106292975 1.217 PIK3CG
phosphoinositide-3-kinase, catalytic, gamma polypeptide
chr7_-_99355065 1.197 TRIM4
tripartite motif containing 4
chr4_-_915868 1.189 GAK
cyclin G associated kinase
chr7_-_128482059 1.181 TNPO3
transportin 3
chr1_+_27521333 1.181 LOC644961
TMEM222
actin, gamma 1 pseudogene
transmembrane protein 222
chr12_-_104153920 1.180 NM_018171
APPL2
adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 2
chr6_-_125664913 1.179 NM_016063
HDDC2
HD domain containing 2
chr4_+_2906403 1.178 C4orf10
chromosome 4 open reading frame 10
chr2_-_54051290 1.173 NM_014614
PSME4
proteasome (prosome, macropain) activator subunit 4
chr20_+_43028590 1.169 STK4
serine/threonine kinase 4
chr10_+_75174151 1.167 SEC24C
SEC24 family, member C (S. cerevisiae)
chr12_+_50592379 1.147 NM_001077401
ACVRL1
activin A receptor type II-like 1
chr8_-_68136881 1.144 COPS5
COP9 constitutive photomorphogenic homolog subunit 5 (Arabidopsis)
chr1_-_27159462 1.140 NM_152365
C1orf172
chromosome 1 open reading frame 172
chr1_+_229731021 1.139 NM_005999
TSNAX-DISC1
TSNAX
TSNAX-DISC1 read-through gene
translin-associated factor X
chr4_-_140224794 1.138 ELF2
E74-like factor 2 (ets domain transcription factor)
chr6_-_33398656 1.136 NM_001141969
NM_001141970
NM_001350
DAXX


death-domain associated protein


chr12_+_8958397 1.136 NM_004426
PHC1
polyhomeotic homolog 1 (Drosophila)
chr16_-_30301357 1.136 SEPT1
septin 1
chr5_-_60493903 1.135 C5orf43
chromosome 5 open reading frame 43
chr7_-_44891471 1.126 NM_033224
PURB
purine-rich element binding protein B
chr6_+_33347833 1.121 RPS18
ribosomal protein S18
chr21_+_46530725 1.120 YBEY
ybeY metallopeptidase (putative)
chr11_-_60885928 1.118 CYBASC3
cytochrome b, ascorbate dependent 3
chr22_-_17799177 1.116 HIRA
HIR histone cell cycle regulation defective homolog A (S. cerevisiae)
chr11_+_65485735 1.115 NM_005146
SART1
squamous cell carcinoma antigen recognized by T cells
chr2_-_27147995 1.115 NM_001134693
OST4
oligosaccharyltransferase 4 homolog (S. cerevisiae)
chr16_+_68353738 1.112 NM_007014
NM_199423
WWP2

WW domain containing E3 ubiquitin protein ligase 2

chr12_-_119116848 1.112 NM_006836
GCN1L1
GCN1 general control of amino-acid synthesis 1-like 1 (yeast)
chr9_-_130124820 1.109 TRUB2
TruB pseudouridine (psi) synthase homolog 2 (E. coli)
chr12_-_46786107 1.103 SENP1
SUMO1/sentrin specific peptidase 1
chr11_+_123997983 1.102 TBRG1
transforming growth factor beta regulator 1
chr10_-_88707299 1.100 NM_024756
MMRN2
multimerin 2
chr7_+_106293112 1.098 NM_002649
PIK3CG
phosphoinositide-3-kinase, catalytic, gamma polypeptide
chr9_+_130124873 1.095 COQ4
coenzyme Q4 homolog (S. cerevisiae)
chr11_+_65164767 1.093 SIPA1
signal-induced proliferation-associated 1
chr7_-_91995684 1.090 NM_000466
PEX1
peroxisomal biogenesis factor 1
chr1_-_1580266 1.090 CDK11A
CDK11B
cyclin-dependent kinase 11A
cyclin-dependent kinase 11B
chr20_+_28225511 1.089 LOC283788
FRG1B
FSHD region gene 1 pseudogene
FSHD region gene 1 family, member B
chr10_+_114144512 1.089 ACSL5
acyl-CoA synthetase long-chain family member 5
chr17_+_32380287 1.088 NM_012138
AATF
apoptosis antagonizing transcription factor
chr1_+_61642287 1.085 NFIA
nuclear factor I/A
chr11_-_60953848 1.085 NM_024811
CPSF7
cleavage and polyadenylation specific factor 7, 59kDa
chr3_-_20202622 1.083 NM_001012409
NM_001012410
NM_001012411
NM_001012412
NM_001012413
NM_138484
SGOL1





shugoshin-like 1 (S. pombe)





chr2_+_64604940 1.082 NM_001002243
NM_017657
NM_203437
AFTPH


aftiphilin


chr2_-_201461945 1.082 NM_032472
NM_130906
PPIL3

peptidylprolyl isomerase (cyclophilin)-like 3

chr21_+_44256601 1.079 TRAPPC10
trafficking protein particle complex 10
chr10_+_75174125 1.077 NM_004922
NM_198597
SEC24C

SEC24 family, member C (S. cerevisiae)

chr17_-_24013013 1.077 NM_006923
SDF2
stromal cell-derived factor 2
chr11_-_95296903 1.077 NM_016156
NM_201278
NM_201281
MTMR2


myotubularin related protein 2


chr10_+_1092295 1.076 WDR37
WD repeat domain 37
chr3_+_20056527 1.074 NM_003884
KAT2B
K(lysine) acetyltransferase 2B
chr17_+_6858815 1.072 C17orf49
chromosome 17 open reading frame 49
chr1_+_164004789 1.070 LOC100147773
hypothetical LOC100147773
chr15_+_62921134 1.063 NM_001195059
NM_025201
PLEKHO2

pleckstrin homology domain containing, family O member 2

chr20_+_43478120 1.063 NM_001184728
NM_001184729
NM_001184730
NM_015937
PIGT



phosphatidylinositol glycan anchor biosynthesis, class T



chr1_+_148305965 1.062 NM_007259
VPS45
vacuolar protein sorting 45 homolog (S. cerevisiae)
chr9_+_131605215 1.056 NM_014506
TOR1B
torsin family 1, member B (torsin B)
chr2_-_46697689 1.055 NM_002643
NM_173074
PIGF

phosphatidylinositol glycan anchor biosynthesis, class F

chr19_+_55918405 1.053 NM_002975
CLEC11A
C-type lectin domain family 11, member A
chr7_-_99355085 1.053 NM_033017
NM_033091
TRIM4

tripartite motif containing 4

chr22_-_19543069 1.049 NM_058004
PI4KA
phosphatidylinositol 4-kinase, catalytic, alpha
chr3_+_198153953 1.044 LOC152217
hypothetical LOC152217
chr1_+_37712716 1.043 ZC3H12A
zinc finger CCCH-type containing 12A
chr9_+_35739321 1.043 RGP1
RGP1 retrograde golgi transport homolog (S. cerevisiae)
chr17_-_76883656 1.042 SLC38A10
solute carrier family 38, member 10
chr9_-_37775064 1.033 NM_016042
NM_001002269
EXOSC3

exosome component 3

chr9_+_130173458 1.033 URM1
ubiquitin related modifier 1
chr16_+_67931033 1.033 NM_016101
NIP7
nuclear import 7 homolog (S. cerevisiae)
chr19_+_44589297 1.032 NM_003407
ZFP36
zinc finger protein 36, C3H type, homolog (mouse)
chr2_-_32118323 1.030 NM_032574
DPY30
dpy-30 homolog (C. elegans)
chr9_-_122595413 1.029 FBXW2
F-box and WD repeat domain containing 2
chr1_+_45926433 1.029 NM_016486
TMEM69
transmembrane protein 69
chr17_-_59923547 1.028 NM_007215
POLG2
polymerase (DNA directed), gamma 2, accessory subunit
chr2_-_241690365 1.028 NM_182501
MTERFD2
MTERF domain containing 2
chr13_-_45524846 1.026 NM_015070
ZC3H13
zinc finger CCCH-type containing 13
chr3_+_57517013 1.025 NM_177966
PDE12
phosphodiesterase 12
chr9_+_138677197 1.025 NM_201446
NM_016215
EGFL7

EGF-like-domain, multiple 7

chr5_-_107744423 1.024 FBXL17
F-box and leucine-rich repeat protein 17
chr10_-_51293220 1.023 NM_006327
TIMM23
TIMM23B
translocase of inner mitochondrial membrane 23 homolog (yeast)
translocase of inner mitochondrial membrane 23 homolog B (yeast)
chr3_+_15444056 1.020 NM_033083
EAF1
ELL associated factor 1
chr20_+_42537927 1.020 NM_001039199
NM_024331
TTPAL

tocopherol (alpha) transfer protein-like

chr3_-_95264349 1.019 NM_176815
DHFRL1
dihydrofolate reductase-like 1
chr2_-_174968595 1.015 NM_004882
CIR1
corepressor interacting with RBPJ, 1
chr6_+_18263514 1.014 NM_153042
KDM1B
lysine (K)-specific demethylase 1B
chr11_+_10729357 1.013 NM_014633
CTR9
Ctr9, Paf1/RNA polymerase II complex component, homolog (S. cerevisiae)
chr17_-_77244009 1.012 NM_001039842
C17orf90
chromosome 17 open reading frame 90
chr1_+_19796119 1.012


chr5_+_140051325 1.011 HARS2
histidyl-tRNA synthetase 2, mitochondrial (putative)
chr4_-_4300821 1.011 NM_032927
TMEM128
transmembrane protein 128
chr8_+_11179724 1.007 MTMR9
myotubularin related protein 9
chr2_+_98591492 1.007 UNC50
unc-50 homolog (C. elegans)
chr16_-_67930974 1.005 NM_032382
COG8
component of oligomeric golgi complex 8
chr8_-_146199064 1.004 ZNF252
zinc finger protein 252
chr9_+_114289178 1.002 KIAA1958
KIAA1958
chr20_+_33750645 1.000 NM_080748
ROMO1
reactive oxygen species modulator 1
chr6_-_153365480 0.993 MTRF1L
mitochondrial translational release factor 1-like
chr5_+_140051404 0.992 HARS2
histidyl-tRNA synthetase 2, mitochondrial (putative)
chr22_-_28279643 0.991 NM_001002878
NM_001002879
NM_001002877
NM_003678
THOC5



THO complex 5



chr15_-_50648636 0.991 ARPP19
cAMP-regulated phosphoprotein, 19kDa
chr2_+_187162969 0.987 NM_001145000
NM_002210
ITGAV

integrin, alpha V (vitronectin receptor, alpha polypeptide, antigen CD51)

chr2_+_74535700 0.984 NM_031288
INO80B
INO80 complex subunit B
chr1_-_39111422 0.980 NM_012333
MYCBP
c-myc binding protein
chr6_+_30402599 0.980 NM_021253
TRIM39
tripartite motif containing 39
chr11_-_57054756 0.977 NM_012456
TIMM10
translocase of inner mitochondrial membrane 10 homolog (yeast)
chr4_-_101086891 0.976 NM_001031723
DNAJB14
DnaJ (Hsp40) homolog, subfamily B, member 14
chr10_-_51041156 0.973 NM_003631
AGAP8
LOC728407
PARG
ArfGAP with GTPase domain, ankyrin repeat and PH domain 8
poly(ADP-ribose) glycohydrolase pseudogene
poly (ADP-ribose) glycohydrolase
chr9_-_126217510 0.969 NM_002799
PSMB7
proteasome (prosome, macropain) subunit, beta type, 7
chr11_-_117628211 0.967 NM_198275
MPZL3
myelin protein zero-like 3

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
1.39 1.30e-49 GO:0044260 cellular macromolecule metabolic process
1.33 1.93e-41 GO:0043170 macromolecule metabolic process
1.48 6.22e-32 GO:0090304 nucleic acid metabolic process
1.41 1.23e-29 GO:0006139 nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
1.23 3.02e-29 GO:0044237 cellular metabolic process
1.42 7.97e-28 GO:0044267 cellular protein metabolic process
1.51 1.31e-26 GO:0016070 RNA metabolic process
1.47 3.77e-24 GO:0010467 gene expression
1.21 5.08e-24 GO:0044238 primary metabolic process
1.19 2.59e-23 GO:0008152 metabolic process
1.97 1.75e-20 GO:0016032 viral reproduction
1.84 3.23e-20 GO:0016071 mRNA metabolic process
1.32 2.68e-19 GO:0019538 protein metabolic process
1.30 3.18e-19 GO:0034641 cellular nitrogen compound metabolic process
1.75 3.27e-19 GO:0006396 RNA processing
1.29 3.08e-18 GO:0006807 nitrogen compound metabolic process
1.32 7.42e-18 GO:0071841 cellular component organization or biogenesis at cellular level
1.27 2.68e-17 GO:0071840 cellular component organization or biogenesis
1.42 6.82e-17 GO:0034645 cellular macromolecule biosynthetic process
1.41 7.72e-17 GO:0009059 macromolecule biosynthetic process
1.41 1.10e-15 GO:0006996 organelle organization
1.52 2.77e-15 GO:0007049 cell cycle
1.70 3.54e-15 GO:0000278 mitotic cell cycle
1.75 4.61e-15 GO:0006974 response to DNA damage stimulus
1.67 1.87e-14 GO:0009057 macromolecule catabolic process
1.72 4.28e-14 GO:0044265 cellular macromolecule catabolic process
1.29 1.15e-13 GO:0071842 cellular component organization at cellular level
1.25 3.51e-13 GO:0016043 cellular component organization
1.09 1.59e-12 GO:0009987 cellular process
1.79 1.66e-12 GO:0006397 mRNA processing
1.53 3.58e-12 GO:0033554 cellular response to stress
1.57 7.94e-12 GO:0022403 cell cycle phase
1.51 1.27e-11 GO:0015031 protein transport
1.87 1.66e-11 GO:0008380 RNA splicing
2.03 1.71e-11 GO:0000075 cell cycle checkpoint
1.52 2.64e-11 GO:0022402 cell cycle process
2.07 4.17e-11 GO:0022613 ribonucleoprotein complex biogenesis
1.99 4.68e-11 GO:0071156 regulation of cell cycle arrest
1.49 5.02e-11 GO:0045184 establishment of protein localization
1.77 7.79e-11 GO:0030163 protein catabolic process
2.02 8.89e-11 GO:0071843 cellular component biogenesis at cellular level
1.80 1.33e-10 GO:0051603 proteolysis involved in cellular protein catabolic process
1.51 1.37e-10 GO:0046907 intracellular transport
1.82 1.69e-10 GO:0006511 ubiquitin-dependent protein catabolic process
1.43 2.49e-10 GO:0008104 protein localization
1.81 3.06e-10 GO:0006412 translation
1.80 3.23e-10 GO:0043632 modification-dependent macromolecule catabolic process
1.78 3.34e-10 GO:0044257 cellular protein catabolic process
2.01 3.38e-10 GO:0000375 RNA splicing, via transesterification reactions
2.02 4.16e-10 GO:0000377 RNA splicing, via transesterification reactions with bulged adenosine as nucleophile
2.02 4.16e-10 GO:0000398 nuclear mRNA splicing, via spliceosome
1.79 4.35e-10 GO:0019941 modification-dependent protein catabolic process
1.81 7.49e-10 GO:0051329 interphase of mitotic cell cycle
1.31 1.13e-09 GO:0006464 protein modification process
1.40 1.14e-09 GO:0044248 cellular catabolic process
1.79 1.41e-09 GO:0051325 interphase
1.30 2.33e-09 GO:0043412 macromolecule modification
1.54 4.36e-09 GO:0051726 regulation of cell cycle
2.06 1.21e-08 GO:0010498 proteasomal protein catabolic process
2.06 1.21e-08 GO:0043161 proteasomal ubiquitin-dependent protein catabolic process
1.71 1.36e-08 GO:0010564 regulation of cell cycle process
1.35 1.55e-08 GO:0033036 macromolecule localization
2.13 1.12e-07 GO:0007093 mitotic cell cycle checkpoint
1.24 1.55e-07 GO:0044249 cellular biosynthetic process
1.23 2.31e-07 GO:0009058 biosynthetic process
1.77 2.74e-07 GO:0016567 protein ubiquitination
1.36 3.08e-07 GO:0051649 establishment of localization in cell
2.18 3.64e-07 GO:0000084 S phase of mitotic cell cycle
2.40 4.78e-07 GO:0000216 M/G1 transition of mitotic cell cycle
2.19 4.93e-07 GO:0000077 DNA damage checkpoint
2.10 5.13e-07 GO:0042254 ribosome biogenesis
1.73 6.39e-07 GO:0032446 protein modification by small protein conjugation
1.66 8.02e-07 GO:0070647 protein modification by small protein conjugation or removal
1.33 8.88e-07 GO:0051641 cellular localization
1.31 8.97e-07 GO:0009056 catabolic process
2.14 9.51e-07 GO:0051320 S phase
1.69 9.88e-07 GO:0048285 organelle fission
2.12 1.11e-06 GO:0031570 DNA integrity checkpoint
2.34 1.56e-06 GO:0031145 anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process
1.68 1.69e-06 GO:0000087 M phase of mitotic cell cycle
1.48 3.04e-06 GO:0006259 DNA metabolic process
2.43 4.64e-06 GO:0051436 negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
2.28 4.76e-06 GO:2000045 regulation of G1/S transition of mitotic cell cycle
2.32 4.91e-06 GO:0051439 regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
1.67 5.14e-06 GO:0000280 nuclear division
1.67 5.14e-06 GO:0007067 mitosis
1.70 5.95e-06 GO:0007346 regulation of mitotic cell cycle
1.62 7.14e-06 GO:0006281 DNA repair
2.39 8.58e-06 GO:0031571 mitotic cell cycle G1/S transition DNA damage checkpoint
2.29 8.58e-06 GO:0031575 mitotic cell cycle G1/S transition checkpoint
2.29 8.58e-06 GO:0071779 G1/S transition checkpoint
1.36 9.18e-06 GO:0032774 RNA biosynthetic process
2.47 1.04e-05 GO:0006977 DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest
2.47 1.04e-05 GO:0072395 signal transduction involved in cell cycle checkpoint
2.47 1.04e-05 GO:0072401 signal transduction involved in DNA integrity checkpoint
2.47 1.04e-05 GO:0072404 signal transduction involved in G1/S transition checkpoint
2.47 1.04e-05 GO:0072413 signal transduction involved in mitotic cell cycle checkpoint
2.47 1.04e-05 GO:0072422 signal transduction involved in DNA damage checkpoint
2.47 1.04e-05 GO:0072431 signal transduction involved in mitotic cell cycle G1/S transition DNA damage checkpoint
2.47 1.04e-05 GO:0072474 signal transduction involved in mitotic cell cycle G1/S checkpoint
2.35 1.17e-05 GO:0051437 positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
1.37 1.20e-05 GO:0008219 cell death
1.56 1.20e-05 GO:0006886 intracellular protein transport
2.41 1.50e-05 GO:0071158 positive regulation of cell cycle arrest
2.31 1.54e-05 GO:0006353 transcription termination, DNA-dependent
1.93 1.76e-05 GO:0000082 G1/S transition of mitotic cell cycle
2.17 2.02e-05 GO:0051438 regulation of ubiquitin-protein ligase activity
1.37 2.07e-05 GO:0016265 death
2.32 2.76e-05 GO:0051352 negative regulation of ligase activity
2.32 2.76e-05 GO:0051444 negative regulation of ubiquitin-protein ligase activity
1.66 2.91e-05 GO:0034660 ncRNA metabolic process
2.53 2.96e-05 GO:0006521 regulation of cellular amino acid metabolic process
2.24 3.37e-05 GO:0051443 positive regulation of ubiquitin-protein ligase activity
2.17 3.72e-05 GO:0030330 DNA damage response, signal transduction by p53 class mediator
1.47 3.88e-05 GO:0070727 cellular macromolecule localization
1.46 7.31e-05 GO:0034613 cellular protein localization
1.56 7.99e-05 GO:0051301 cell division
1.55 8.96e-05 GO:0044419 interspecies interaction between organisms
1.76 9.20e-05 GO:0034470 ncRNA processing
1.16 9.39e-05 GO:0060255 regulation of macromolecule metabolic process
2.05 1.05e-04 GO:0006414 translational elongation
2.08 1.27e-04 GO:0051340 regulation of ligase activity
1.79 1.62e-04 GO:0043687 post-translational protein modification
1.37 1.69e-04 GO:0016192 vesicle-mediated transport
2.19 1.71e-04 GO:0006354 transcription elongation, DNA-dependent
2.13 2.41e-04 GO:0051351 positive regulation of ligase activity
1.53 2.45e-04 GO:0016568 chromatin modification
1.98 2.88e-04 GO:0042770 signal transduction in response to DNA damage
1.28 3.38e-04 GO:0044085 cellular component biogenesis
1.96 4.23e-04 GO:0031398 positive regulation of protein ubiquitination
2.08 4.37e-04 GO:0006415 translational termination
1.37 4.73e-04 GO:0006915 apoptosis
1.47 6.15e-04 GO:0000279 M phase
1.82 6.66e-04 GO:0031396 regulation of protein ubiquitination
2.06 6.74e-04 GO:0031397 negative regulation of protein ubiquitination
1.33 8.45e-04 GO:0043933 macromolecular complex subunit organization
1.66 9.96e-04 GO:0033365 protein localization to organelle
2.22 1.06e-03 GO:0033238 regulation of cellular amine metabolic process
2.41 1.16e-03 GO:0050434 positive regulation of viral transcription
2.06 1.25e-03 GO:0019080 viral genome expression
2.06 1.25e-03 GO:0019083 viral transcription
2.11 1.32e-03 GO:0031123 RNA 3'-end processing
1.43 1.39e-03 GO:0034621 cellular macromolecular complex subunit organization
1.35 1.75e-03 GO:0012501 programmed cell death
1.97 1.84e-03 GO:0043241 protein complex disassembly
1.97 1.84e-03 GO:0043624 cellular protein complex disassembly
2.24 1.94e-03 GO:0006368 transcription elongation from RNA polymerase II promoter
2.29 2.07e-03 GO:0046782 regulation of viral transcription
2.15 2.09e-03 GO:0072594 establishment of protein localization to organelle
1.90 2.35e-03 GO:0032984 macromolecular complex disassembly
1.90 2.35e-03 GO:0034623 cellular macromolecular complex disassembly
2.09 2.81e-03 GO:0000209 protein polyubiquitination
2.01 2.88e-03 GO:0071826 ribonucleoprotein complex subunit organization
1.99 3.15e-03 GO:0006364 rRNA processing
1.90 3.18e-03 GO:0090068 positive regulation of cell cycle process
2.03 3.56e-03 GO:0022618 ribonucleoprotein complex assembly
1.64 3.80e-03 GO:0006605 protein targeting
1.72 5.22e-03 GO:0022415 viral reproductive process
1.37 5.24e-03 GO:0071822 protein complex subunit organization
1.77 5.40e-03 GO:0010565 regulation of cellular ketone metabolic process
1.92 7.20e-03 GO:0016072 rRNA metabolic process
1.65 7.59e-03 GO:0006260 DNA replication
2.13 8.44e-03 GO:0031124 mRNA 3'-end processing
1.76 9.69e-03 GO:0019058 viral infectious cycle
1.41 1.08e-02 GO:0016044 cellular membrane organization
1.94 1.26e-02 GO:0018196 peptidyl-asparagine modification
1.94 1.26e-02 GO:0018279 protein N-linked glycosylation via asparagine
1.74 1.29e-02 GO:0007005 mitochondrion organization
1.90 1.40e-02 GO:0006487 protein N-linked glycosylation
1.40 1.46e-02 GO:0061024 membrane organization
1.52 1.48e-02 GO:0010608 posttranscriptional regulation of gene expression
1.63 1.56e-02 GO:0022411 cellular component disassembly
1.63 1.56e-02 GO:0071845 cellular component disassembly at cellular level
2.10 1.82e-02 GO:0048524 positive regulation of viral reproduction
1.34 2.31e-02 GO:0051276 chromosome organization
1.93 2.33e-02 GO:0051168 nuclear export
1.12 2.64e-02 GO:0019222 regulation of metabolic process
1.26 2.78e-02 GO:0032268 regulation of cellular protein metabolic process
2.32 2.90e-02 GO:0006369 termination of RNA polymerase II transcription
1.44 2.96e-02 GO:0018193 peptidyl-amino acid modification
1.24 3.79e-02 GO:0051246 regulation of protein metabolic process
1.57 4.27e-02 GO:0006457 protein folding
1.27 4.51e-02 GO:0006351 transcription, DNA-dependent
1.61 4.56e-02 GO:0051169 nuclear transport

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.19 2.74e-74 GO:0044424 intracellular part
1.18 7.72e-73 GO:0005622 intracellular
1.24 2.52e-62 GO:0043231 intracellular membrane-bounded organelle
1.24 2.85e-62 GO:0043227 membrane-bounded organelle
1.21 2.51e-59 GO:0043229 intracellular organelle
1.20 7.60e-59 GO:0043226 organelle
1.30 5.18e-43 GO:0005634 nucleus
1.55 5.43e-43 GO:0044428 nuclear part
1.29 3.10e-42 GO:0044446 intracellular organelle part
1.51 1.60e-41 GO:0031974 membrane-enclosed lumen
1.52 6.87e-41 GO:0070013 intracellular organelle lumen
1.51 7.78e-40 GO:0043233 organelle lumen
1.28 1.49e-39 GO:0044422 organelle part
1.56 8.11e-37 GO:0031981 nuclear lumen
1.19 4.75e-36 GO:0005737 cytoplasm
1.97 8.16e-28 GO:0030529 ribonucleoprotein complex
1.22 1.61e-25 GO:0044444 cytoplasmic part
1.29 1.66e-22 GO:0032991 macromolecular complex
1.49 1.21e-19 GO:0005654 nucleoplasm
1.80 1.52e-18 GO:0005730 nucleolus
1.30 4.74e-17 GO:0043228 non-membrane-bounded organelle
1.30 4.74e-17 GO:0043232 intracellular non-membrane-bounded organelle
1.33 5.60e-15 GO:0005829 cytosol
2.29 3.59e-12 GO:0005681 spliceosomal complex
2.57 2.82e-10 GO:0071013 catalytic step 2 spliceosome
1.22 2.19e-09 GO:0043234 protein complex
1.04 1.82e-08 GO:0044464 cell part
1.04 1.97e-08 GO:0005623 cell
1.89 7.86e-08 GO:0005840 ribosome
1.43 1.27e-07 GO:0044451 nucleoplasm part
1.79 1.48e-07 GO:0016604 nuclear body
1.46 1.98e-06 GO:0005694 chromosome
2.39 6.28e-06 GO:0000502 proteasome complex
1.90 8.44e-06 GO:0000151 ubiquitin ligase complex
1.48 1.49e-05 GO:0044427 chromosomal part
1.27 1.84e-05 GO:0005739 mitochondrion
1.79 8.90e-05 GO:0044445 cytosolic part
1.87 1.84e-04 GO:0016607 nuclear speck
1.19 4.09e-04 GO:0031090 organelle membrane
1.63 4.39e-04 GO:0000228 nuclear chromosome
1.70 4.81e-04 GO:0044454 nuclear chromosome part
1.98 1.38e-03 GO:0000790 nuclear chromatin
2.03 1.56e-03 GO:0022626 cytosolic ribosome
1.31 1.94e-03 GO:0031967 organelle envelope
1.32 3.27e-03 GO:0044429 mitochondrial part
2.76 4.21e-03 GO:0044452 nucleolar part
1.30 4.99e-03 GO:0031975 envelope
1.25 5.63e-03 GO:0005794 Golgi apparatus
2.49 1.14e-02 GO:0030532 small nuclear ribonucleoprotein complex
1.50 1.41e-02 GO:0000785 chromatin
2.00 2.10e-02 GO:0015934 large ribosomal subunit
1.97 2.27e-02 GO:0044450 microtubule organizing center part
1.31 2.37e-02 GO:0044431 Golgi apparatus part
1.46 2.75e-02 GO:0044440 endosomal part
1.49 3.21e-02 GO:0005813 centrosome
1.46 3.46e-02 GO:0010008 endosome membrane
1.34 3.59e-02 GO:0005768 endosome
1.39 4.73e-02 GO:0005815 microtubule organizing center

Gene overrepresentation in function category:

enrichment   p-value GO term description
1.20 4.93e-30 GO:0005515 protein binding
1.10 6.72e-21 GO:0005488 binding
1.62 6.80e-19 GO:0003723 RNA binding
1.28 6.05e-18 GO:0003676 nucleic acid binding
1.13 9.20e-07 GO:0003824 catalytic activity
1.74 3.46e-06 GO:0004842 ubiquitin-protein ligase activity
1.87 1.61e-05 GO:0003735 structural constituent of ribosome
1.68 2.22e-05 GO:0019787 small conjugating protein ligase activity
1.86 7.29e-05 GO:0004386 helicase activity
1.97 1.13e-04 GO:0008026 ATP-dependent helicase activity
1.97 1.13e-04 GO:0070035 purine NTP-dependent helicase activity
1.19 2.10e-04 GO:0000166 nucleotide binding
1.20 2.84e-04 GO:0008270 zinc ion binding
1.21 8.44e-04 GO:0016740 transferase activity
1.41 1.46e-03 GO:0016874 ligase activity
1.54 1.77e-03 GO:0016881 acid-amino acid ligase activity
1.96 1.83e-03 GO:0008565 protein transporter activity
1.68 1.84e-03 GO:0008168 methyltransferase activity
1.31 2.22e-03 GO:0019899 enzyme binding
1.19 2.28e-03 GO:0017076 purine nucleotide binding
1.52 2.37e-03 GO:0042623 ATPase activity, coupled
1.19 2.69e-03 GO:0035639 purine ribonucleoside triphosphate binding
1.21 2.89e-03 GO:0030554 adenyl nucleotide binding
1.21 3.69e-03 GO:0032559 adenyl ribonucleotide binding
1.21 3.78e-03 GO:0005524 ATP binding
1.45 4.13e-03 GO:0016887 ATPase activity
1.18 4.26e-03 GO:0032553 ribonucleotide binding
1.18 4.26e-03 GO:0032555 purine ribonucleotide binding
1.48 5.50e-03 GO:0016879 ligase activity, forming carbon-nitrogen bonds
1.63 6.33e-03 GO:0016741 transferase activity, transferring one-carbon groups
1.28 1.48e-02 GO:0016818 hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides
1.27 2.00e-02 GO:0016817 hydrolase activity, acting on acid anhydrides
1.27 2.26e-02 GO:0016462 pyrophosphatase activity
1.37 2.41e-02 GO:0004674 protein serine/threonine kinase activity
1.51 3.09e-02 GO:0003713 transcription coactivator activity
1.86 3.60e-02 GO:0008135 translation factor activity, nucleic acid binding
1.27 3.88e-02 GO:0017111 nucleoside-triphosphatase activity
1.14 4.93e-02 GO:0003677 DNA binding
1.70 4.95e-02 GO:0051082 unfolded protein binding
1.38 4.99e-02 GO:0003712 transcription cofactor activity